You should consult with your veterinarian as soon as possible because as indicated in the comments he is in serious pain and sick, since loss of appetite often indicates illness and vet will be able to help you.
Generic cause of change in eating habit and lost of appetite.
Illness, recent vaccination, unfamiliar environment/surrounding (for travelers), psychological issues (anxiety and depression; yes cats can get depressed as well).
First course of action, consult your vet. Start observing, keeping above causes in mind, lost of appetite is serious, in such a case, fats deposits gives energy but it is processed by liver (requires adequate supplies of protein) so if protein supplies are exhausted and fats overwhelmed liver; can cause liver failure a condition called “hepatic lipidosis”.
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